Why President Trump is at odds with his medical experts over using malaria drugs against Covid-19
Clinical trials document that prophylaxis with once-weekly Zithromax reduced the risk of developing MAC bacteria in the bloodstream and the clinical signs and symptoms associated with it. Two randomized, double-blind trials conducted in people with advanced HIV infection demonstrated that Zithromax effectively reduced the risk of developing disseminated MAC.
In one of these pivotal studies, Zithromax was compared to rifabutin and the combination of these two agents. In this large double-blind study, there was a statistically significant difference in favor of Zithromax in the one-year cumulative incidence rate of disseminated MAC. Additionally, Zithromax-rifabutin combination therapy was to be more effective than rifabutin as monotherapy.
Formal drug interaction studies have demonstrated that Zithromax can be used concomitantly with many medications commonly prescribed for subjects with advanced HIV infections, such as zidovudine, didanosine, or rifabutin, without dosage adjustments. Currently, no data are available evaluating the concomitant use of Zithromax and the recently approved protease inhibitors. Overall side effects in Zithromax-treated subjects were primarily mild to moderate in nature and consisted mainly of diarrhea, nausea, abdominal pain, and loose stools.
Gastrointestinal side effects observed in subjects treated with Zithromax were statistically greater than those observed in the rifabutin-treated subjects.
There was no statistically significant difference in discontinuations due to side effects among the treatment groups. Zithromax is contraindicated in subjects with known hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic.
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This medicine may mask or delay the symptoms of syphilis. It is not effective against syphilis infections. Azithromycin belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.
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