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In systemic lupus, discoid lupus, and rheumatoid arthritis Plaquenil helps alleviate or prevent symptoms caused by the body's inflammatory response, such as swelling and pain. For these conditions Plaquenil is usually taken once or twice per day, ideally at the same times each day.

Patients are typically started on smaller doses, which are increased if needed and no adverse effects develop. Treatment may be for just a few weeks but more commonly spans months, if not longer. Most patients find to mg per day to be sufficient, though more rarely some individuals require to mg per day.

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If taking long-term, the lowest effective dose is desirable to reduce the likelihood of side effects. It may take several weeks of regular treatment for full benefit to be felt, particularly in arthritis. While most people take Plaquenil without any issues, it can produce an odd assortment of side effects in some patients, particularly if taken long-term:. A rare but potentially serious eye issue, retinopathy, is associated with Plaquenil. The condition, which involves deterioration of the retina, can develop without symptoms until damage has been done.

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